Health & Environmental Research Online (HERO)


Print Feedback Export to File
11910784 
Journal Article 
Review 
Herbal medicines for advanced colorectal cancer 
Guo, Z; Jia, X; Liu, JP; Liao, J; Yang, Y 
2012 
Yes 
Cochrane Database of Systematic Reviews
ISSN: 1469-493X 
5 
CD004653 
English 
22592697 
has retraction 4800793 WITHDRAWN:
BACKGROUND: Herbal medicine has been widely used in patients with advanced colorectal cancer in China, but its efficacy has not been confirmed.

OBJECTIVES: To evaluate the beneficial effect and safety on Chinese herbal medicine therapy for advanced stage colorectal cancer, and it's influence on the patients' quality of life.

SEARCH METHODS: The following electronic databases were searched: BIOSIS Previews, Cochrane Controlled Trials Register, Medline EMBASE, Biological Abstracts, until Aug. 2011. Manual searching was performed on 16 types of Chinese journals which started from their respective first publication dates, as well as unpublished conference proceedings. No language restriction was applied.

SELECTION CRITERIA: Randomized or quasi-randomised controlled trials on the treatment of advanced stage colorectal cancer by herbal medicines or herbal medicines combined with chemotherapy, regardless of blinding.

DATA COLLECTION AND ANALYSIS: The data were extracted independently by two reviewers. Methodological quality of the included in trials was assessed according to the following parameters: randomisation, allocation concealment, double blinding, and drop-out rates.

MAIN RESULTS: A total of 20 randomised controlled trials with 1304 participants were identified. All the 20 trials compared the use of herbal medicines with chemotherapy and chemotherapy alone in the treatment of advanced stage colorectal cancers.Compared with chemotherapy alone, the use of Quxie capsule combined with chemotherapy could decrease mortality rate (RR 0.17, 95% CI 0.03 to 0.97); the use of Jianpi Jiedu formula, Xiaozheng formula and Yiqi Huoxue herbal medicine combined with chemotherapy respectively could improve 1-year survival rate significantly; the use of Xiaozheng Formula in conjunction with chemotherapy could improve 3-year survival rate. There were 10 herbal medicines showing benefit in improving quality of life. Herbal medicines did not show additional benefit in response rate or stability rate. No trials reported serious adverse effect from herbal medicine.

AUTHORS' CONCLUSIONS: Some herbal medicines combined chemotherapy compared with chemotherapy alone showed more beneficial effects in improving 1-year, 3-year survival and quality of life.