Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1222898
Reference Type
Journal Article
Subtype
Review
Title
Endogenous versus exogenous DNA adducts: Their role in carcinogenesis, epidemiology, and risk assessment
Author(s)
Swenberg, JA; Lu, K; Moeller, BC; Gao, L; Upton, PB; Nakamura, J; Starr, TB
Year
2011
Is Peer Reviewed?
1
Journal
Toxicological Sciences
ISSN:
1096-6080
EISSN:
1096-0929
Volume
120
Issue
Suppl 1
Page Numbers
S130-S145
Language
English
PMID
21163908
DOI
10.1093/toxsci/kfq371
Web of Science Id
WOS:000287748400008
URL
http://
://WOS:000287748400008
Exit
Abstract
There is a strong need for science-based risk assessment that utilizes known data from diverse sources to arrive at accurate assessments of human health risk. Such assessments will protect the public health without mandating unreasonable regulation. This paper utilizes 30 years of research on three "known human carcinogens": formaldehyde, vinyl chloride (VC), and ethylene oxide (EO), each of which forms DNA adducts identical to endogenous DNA adducts in all individuals. It outlines quantitative data on endogenous adducts, mutagenicity, and relationships between endogenous and exogenous adducts. Formaldehyde has the richest data set, with quantitative data on endogenous and exogenous DNA adducts from the same samples. The review elaborates on how such data can be used to inform the current risk assessment on formaldehyde, including both the biological plausibility and accuracy of projected risks. Finally, it extends the thought process to VC, EO, and additional areas of potential research, pointing out needs, nuances, and potential paths forward to improved understanding that will lead to strong science-based risk assessment.
Keywords
DNA adducts; endogenous; exogenous; carcinogenesis; epidemiology; risk assessment
Tags
•
Formaldehyde
Prior to 2013 Search
Toxicokinetics
Cited in text
Other
•
Project 9 – Soil and Dust Ingestion
Cited October 2016
Supplemental Information - Cited
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity