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1268469 
Journal Article 
Abstract 
Suppression of delayed hypersensitivity to beryllium in guinea pigs by cyclophosphamide 
Krivanek, ND; Reeves, AL 
1973 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
25 
3 
476 
English 
WOS:A1973Q218800111 
is part of a larger document 3114922 Abstracts of papers for the Twelfth Annual Meeting of the Society of Toxicology, New York, New York March 18–22, 1973
Ten female guinea pigs were given cyclophosphamide (CPA), ip (20 mg/kg) for 9 consecutive days. On day 7 of CPA treatment, the animals received 0.1 ml of a solution containing 5.0 μg Be (as SO4) intradermally in an attempt to induce sensitization to the beryllium. Fourteen days after the sensitizing challenge the animals were skin tested for beryllium hypersensitivity. These skin reactions were compared statistically to skin reactions of guinea pigs which had received identical sensitization injections but did not receive CPA. The results of this comparison indicated that the CPA prevented the development of delayed cutaneous hypersensitivity to beryllium. In a group of previously beryllium-sensitized guinea pigs, CPA was given for 3 days (20 mg/kg) and on day 3 the animals were skin tested for beryllium hypersensitivity. The results of the skin testing indicated that CPA was not effective in suppressing previously established beryllium hypersensitivity in guinea pigs. 
Twelfth Annual Meeting of the Society of Toxicology 
New York 
March 18–22, 1973