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1313413 
Journal Article 
Respiratory symptoms and lung function in foundry workers using the hot box method: A 4-year follow-up 
Löfstedt, H; Westberg, H; Seldén, AI; Bryngelsson, IL; Svartengren, M 
2011 
Yes 
Journal of Occupational and Environmental Medicine
ISSN: 1076-2752
EISSN: 1536-5948 
53 
12 
1425-1429 
English 
uses data from 5943728 Exposure to low molecular weight isocyanates and formaldehyde in foundries using Hot Box core binders
OBJECTIVE: To perform follow-up of lung function and respiratory and ocular symptoms in foundry workers exposed to monoisocyanates using the Hot Box method.

METHODS: Four years after an initial assessment, 25 foundry workers and 55 referents completed a questionnaire and were assessed by spirometry pre- and postshift. Exposure to isocyanic acid, methyl isocyanate, and formaldehyde was measured.

RESULTS: Exposure levels were reduced by 50% at follow-up. A high prevalence of nasal and ocular symptoms remained in both groups, but lower airway symptoms had decreased. Lung function preshift was lower for the exposed group, but lung function over shift was unaffected.

CONCLUSIONS: The high prevalence of nasal symptoms and the small reduction of forced expiratory volume in 1 second preshift in exposed foundry workers at follow-up may indicate a prolonged influence of previous exposure in the working environment despite reduced exposure levels at follow-up. 
Adult; Copper/adverse effects; Follow-Up Studies; Formaldehyde/adverse effects; Isocyanates/ adverse effects; Lung/ physiology; Middle Aged; Occupational Diseases/chemically induced/ epidemiology/physiopathology; Occupational Exposure/ adverse effects; Prevalence; Respiratory Tract Diseases/chemically induced/ epidemiology/physiopathology; Spirometry; Zinc/adverse effects 
• Formaldehyde [archived]
     Pulmonary Function
          Found
          Screened
               Title/Abstract Screen
                    Duplicates
               Abstract/Full Text Screen
                    Human- FA
          Cited
     Sensory Irritation
          Found
          Screened
               Included
                    Additional from Reviews
          Cited
     Cited in text
     Immune Section
          Include in evaluation
     Human Respiratory Pathology
          Found
     Retroactive RIS import
          2013
               Formaldehyde Pulm Func Cited 032013
               HERO Formaldehyde Immune Section 20Mar2013
               Lit Tags Pulm Func 091613
                    Considered
                         Considered
               Irritation- Pubmed WOS Sorted
               Respiratory Pathology Pubmed WOS Toxline
                    Respiratory/Irritation
          2014
               Formaldehyde_Irritation_102814
                    Included
                         addl from reviews
               Immune_HERO_allyr
               Respiratory Pathology Pubmed_WOS_Toxline_090414
                    Respiratory/Irritation
• IRIS Formaldehyde (Inhalation) [Final 2024]
     Literature Indexing
          Other sources and cited references
     Literature Identification
          Sensory Irritation in Humans
               Excluded
          Pulmonary Function in Humans
               Met Peco
          Respiratory Tract Pathology in Humans
               Excluded
          Immune-Mediated Conditions in Humans, Including Asthma and Allergy
               Excluded