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Citation
Tags
HERO ID
1313593
Reference Type
Journal Article
Title
Analysis of allergens in metalworking fluids
Author(s)
Henriks-Eckerman, ML; Suuronen, K; Jolanki, R
Year
2008
Is Peer Reviewed?
Yes
Journal
Contact Dermatitis
ISSN:
0105-1873
EISSN:
1600-0536
Volume
59
Issue
5
Page Numbers
261-267
Language
English
PMID
18976375
DOI
10.1111/j.1600-0536.2008.01438.x
Web of Science Id
WOS:000260527800002
URL
http://dx.doi.org/10.1111/j.1600-0536.2008.01438.x
Exit
Abstract
BACKGROUND:
Metalworking fluids (MWFs) are well-known causes of occupational contact dermatitis in machinists.
OBJECTIVE:
To gain information about skin sensitizers in MWFs and to compare it with the information in safety data sheets (SDSs).
METHODS:
A total of 17 samples of MWF concentrates were analysed for skin sensitizers known or suspected to be used in MWF. Alkanolamines, formaldehyde, isothiazolinones, methyldibromo glutaronitrile (MDBGN), and iodopropynyl butylcarbamate (IPBC) were separated by liquid chromatography. Resin acids of colophonium (colophony) were separated by gas chromatography. The substances were identified with mass spectrometric detection and ultraviolet detection.
RESULTS:
Of the MWFs, 15 contained 6-39% of alkanolamines, mostly monoethanolamine and triethanolamine. Formaldehyde was detected in all MWFs: the concentrations of total formaldehyde ranged between 0.002% and 1.3%. Benzisothiazolinone and octylisothiazolinone were detected in one fluid each. IPBC was detected in nine MWFs, and the highest concentration was 0.09%. Methylisothiazolinone and MDBGN were not detected in any of the fluids. Resin acids of colophonium were detected in seven MWFs in concentrations ranging from 0.41% to 3.8%. On the whole, the allergens analysed were poorly declared in the SDSs.
CONCLUSIONS:
The content of total formaldehyde was not declared in any SDS. IPBC, a relatively new allergen, seems to be common in MWFs. Isothiazolinones may be relevant allergens of machinists, and they should be analysed in MWFs in case other sources are not identified. The occupational relevance of positive patch test results to MWF ingredients in machinists is difficult to determine if information in the SDSs is relied upon.
Keywords
alkanolamines; analysis; antimicrobial agents; biocides; colophonium; contact allergens; formaldehyde; iodopropynyl butylcarbamate; isothiazolinones; metalworking fluids; resin acids; safety data sheet
Tags
IRIS
•
Formaldehyde [archived]
Immune Section
Exclude - Contact dermatitis, patch testing studies
Inflammation/Reactive Oxygen Species
WOS
PubMed
Screened by Title/Abstract
Patch testing and/or Contact Allergy Dermatitis (for possible further review)
Retroactive RIS import
2013
HERO Formaldehyde Immune Section 20Mar2013
2014
HERO_Formaldehyde_InflammationReactiveOxygenSpecies_pid_31_uid_5713Sorting091214
HERO_Formaldehyde_InflammationReactiveOxygenSpecies_pid_31_uid_5713
Screened (Title/Abstract)
Patch testing and/or Contact Allergy/Dermatitis (for possible further review)
Immune_HERO_allyr
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
PubMed
WoS
Literature Identification
Immune-Mediated Conditions in Humans, Including Asthma and Allergy
Excluded
Inflammation and Immune-Related Mechanistic Studies
Excluded
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