US EPA

1317252 

Journal Article 

Allergy to Benzylamine and Benzyl-1-amino-3 Chloro-2 Hydroxypropane 

Van Ketel, WG 

1984 

Yes 

Contact Dermatitis
ISSN: 0105-1873
EISSN: 1600-0536 

NIOSH/00173044 

11 

3 

186 

English 

6238790 

The case of a 48 year old chemist who developed a work related dermatitis after handling epichlorohydrin (106898), benzylamine (100469), and benzyl-1-amino-3-chloro-2-hydroxypropane (BACHP) was described. The patient presented with a dermatitis of the hands and face which subsided after a few days away from work. He used the compounds as chemical intermediates in the potential synthesis of agricultural chemicals, and his dermatitis developed shortly after he had contact with the materials. The clinical history included hay fever, and positive inhalation responses to house dust, grass pollen, and animal dander were obtained. A weak reaction to formaldehyde was found in patch tests with the ICDRG standard series. Patch tests to epichlorohydrin were negative. Patch tests to benzylamine and BACHP were positive. These compounds were tested at 0.1 and 1 percent in 70 percent ethanol. Ten comparisons had negative patch tests to these compounds. The author concludes that the positive reactions in the patient are allergic reactions which probably demonstrate cross sensitivity. 

DCN-160026; Chemical manufacturing industry; Amino compounds; Chemical synthesis; Occupational dermatitis; Sensitivity testing; Skin lesions; Chemical hypersensitivity; Allergic reactions