US EPA

1317253 

Journal Article 

Allergic Contact Urticaria Due to Chloramine 

Dooms-Goossens, A; Gevers, D; Mertens, A; Vanderheyden, D 

1983 

Yes 

Contact Dermatitis
ISSN: 0105-1873
EISSN: 1600-0536 

MUNKSGAARD INT PUBL LTD 

COPENHAGEN 

NIOSH/00173025 

9 

4 

319-320 

English 

6225615 

10.1111/j.1600-0536.1983.tb04404.x 

WOS:A1983RB75700020 

http://://WOS:A1983RB75700020
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A case of contact urticaria due to chloramine (10599903) was described in a 52 year old female nurse with no history of atopy. The patient initially presented with recurrent, itchy, erythematous plaques on the back surfaces of both hands. Her job at the hospital required frequent contact with soaps, detergents, antiseptic solutions, and the formaldehyde containing disinfectant, Lysoform. An initial patch test with 0.2 percent chloramine in water was negative. The patient was seen approximately 3 years after the initial visit for recurrent attacks of eyelid edema accompanied by dyspnea, rhinitis, and a tingling sensation in her mouth upon coming into contact with chloramine powder. The symptoms appeared within 20 minutes of chloramine contact and lasted for up to several days. Treatment with a corticosteroid cream was ineffective. An open patch test with the chloramine powder yielded erythema and wheal formation after 20 minutes. The same responses were noted at 2 hours after patch tests with 25 and 50 percent chloramine solutions. Tests with less concentrated solutions were negative. A closed patch test with 0.2 percent chloramine was positive at the 48 hour reading. Oral antihistamine administration cleared the symptoms within 24 hours. A radioimmunoassay of the patient's serum showed a positive immunoglobulin-E reaction with chloramine conjugated to human serum albumin. The authors conclude that the patient can be classified as a stage three contact urticaria syndrome according to the system of Von Krogh and Maibach, with cutaneous and extracutaneous symptoms. 

DCN-160008; Chlorine compounds; Occupational exposure; Sensitivity testing; Skin irritants; Amines; Chemical hypersensitivity; Occupational dermatitis; Contact allergies; Medical personnel; Immunoglobulins