Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1320870

Reference Type

Journal Article

Title

Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception

Author(s)

Li, K; Fu, KY; Light, AR; Mao, J

Year

2010

Is Peer Reviewed?

Yes

Journal

Journal of Neuroimmunology
ISSN: 0165-5728
EISSN: 1872-8421

Volume

221

Issue

1-2

Page Numbers

25-31

Language

English

PMID

20202692

DOI

10.1016/j.jneuroim.2010.02.003

URL

http://dx.doi.org/10.1016/j.jneuroim.2010.02.003
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Abstract

In the present study, intraperitoneal administration of minocycline attenuated enhancing nociceptive behaviors in those rats receiving dual formalin injections (5% formalin followed at 7 days later by 1% formalin). The minocycline treatment did not prevent the increase in OX-42 and MHC class I labeling and morphological changes, but significantly attenuated upregulation of phospho-p38 in activated microglia. These results suggest that the later days of microglial activation with upregulated immune markers in the spinal cord contributes to enhancing long-term pain response by a pathway of p38 activation in microglia.