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HERO ID
1326475
Reference Type
Journal Article
Title
The effect of a prolonged intake of phosphoric acid and citric acid in rats
Author(s)
Bonting, SL; Jansen, BCP
Year
1956
Is Peer Reviewed?
Chk
Journal
Voeding (Netherlands)
ISSN:
0042-7926
Volume
17
Page Numbers
137-148
Language
English
URL
https://www.cabdirect.org/cabdirect/abstract/19561404771
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Abstract
Diets containing 0.40 or 0.75 per cent. H3PO4 or 1.20 per cent. citric acid had no harmful effect on rats, as shown by growth, reproduction, blood analysis, gross and microscopic appearance of the organs and teeth, mineral and N metabolism and tissue composition in 2 successive generations. Rats receiving H3PO4retained more P and excreted more P in the urine. The acid was neutralized by the excretion of ammonia by the kidneys, a phosphate shift resulting in an increased titratable acidity and a decreased pH of the urine and by the excretion of more acid calcium phosphate in the faeces. All extra citric acid was metabolised
Keywords
acidity, ammonia, animal models, blood analysis, calcium, calcium phosphates, citric acid, diets, excretion, faeces, intake, kidneys, reproduction, teeth
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