US EPA

1326574 

Journal Article 

Dermal carcinogenicity study by mouse-skin painting with 2,4-toluendediamine alone or in representative hair dye formulations 

Giles, AL; Chung, CW 

1976 

1 

Journal of Toxicology and Environmental Health
ISSN: 0098-4108 

HEEP/76/08962 

1 

3 

433-440 

English 

813012 

10.1080/15287397609529342 

WOS:A1976BE87100007 

The chronic toxicity of 2,4-toluenediamine (2,4-TDA) alone or in conbination with a hair dye complex (2,5-toluenediamine, p-phenylenediamine, and resorcinol) was studied in Swiss-Webster mice of both sexes by a skin-painting technique. The predominant neoplasms seen in these mice were primary pulmonary adenomas and adenocarcinomas. Skin neoplasms were seen in most groups of mice, including untreated control mice. Statistical analysis of the incidences of skin neoplasms among the various groups of mice did not show any significant differences. The 2,4-TDA alone or mixed with the hair dye complex did not produce any abnormal proliferation and maturation of the squamous epithelium of the skin. The 2,4-TDA under our experimental conditions was found to be nontoxic and noncarcinogenic to the skin of mice. 

2; 2; P-PHENYLENEDIAMINE; RESORCINOL; 7; MALE; FEMALE; ANIMAL; MICE; ANALYSIS; CHEMICALLY INDUCED; INCIDENCE; NEOPLASMS; TOXICITY; SKIN NEOPLASMS; HAIR PREPARATIONS; DIAMINES; LUNG NEOPLASMS