Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1327237
Reference Type
Journal Article
Subtype
Review
Title
Selenium Compounds and Apoptotic Modulation: A New Perspective in Cancer Therapy
Author(s)
Sanmartin, C; Plano, D; Palop, J
Year
2008
Is Peer Reviewed?
1
Journal
Mini - Reviews in Medicinal Chemistry
ISSN:
1389-5575
Volume
8
Issue
10
Page Numbers
1020-1031
Language
English
PMID
18782054
DOI
10.2174/138955708785740625
Web of Science Id
WOS:000259506400006
URL
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-5575&volume=8&issue=10&spage=1020
Exit
Abstract
Recent epidemiological studies have demonstrated that selenium may be an effective chemopreventive and anticancer agent with a broad spectrum against several human cancer cells (prostate, colon, bladder, lung, liver, ovarian, leukemia). A wide range of potential mechanisms have been proposed for the antitumorigenic effects of selenium and these include antiandrogen activity, growth inhibitory effects by regulation of p53 and antioxidant function, and through DNA damage. However, apoptosis is one of the most plausible mechanisms for the anticancer activity. The regulating mechanisms of apoptosis are extremely complex and for selenium compounds they mainly involve a mitochondrial pathway, protein kinases, tumor necrosis factor, activation of caspases and reactive oxygen species. The aim of this review is to summarize the current knowledge about more than twenty eight selenium-containing molecules and to discuss the implications for apoptosis and the impact in cancer therapy.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity