Health & Environmental Research Online (HERO)


Print Feedback Export to File
1334093 
Journal Article 
Interaction of di-2-ethylhexyl phthalate (DEHP) with parathion in rats 
Srivastava, SP; Agarwal, DK; Mushtaq, M; Seth, PK 
1976 
Yes 
Chemosphere
ISSN: 0045-6535
EISSN: 1879-1298 
5 
3 
177-181 
English 
The effect of DEHP was investigated on the acetylcholinesterase (AChE) inhibitory property of parathion. Adult male white rats were divided into 6 groups and treated as follows: 1) DEHP, 5 mg/kg, i.p.; 2) parathion, 4.3 mg/kg in propylene glycol p.o.; 3) paraoxon, 0.5 mg/kg in propylene glycol p.o.; 4) DEHP + parathion; 5) DEHP + paraoxon; and 6) saline + propylene glycol. Parathion significantly inhibited the activity of AChE in blood and brain, while DEHP had no effect in both preparations. Pretreatment of the animals with the plasticizer significantly reduced the degree of enzyme inhibition caused by parathion alone from 56 to 45% in blood and from 51 to 19% in brain. The decrease in the inhibitory property of the pesticide may be due to the effect of DEHP on its biotransformation, distribution, or excretion. Further study suggested that DEHP somehow altered the rate of conversion of parathion to paraoxon. It is suggested from this study that phthalate plasticizers may modify the action of some xenobiotics, perhaps by impeding their metabolic disposition. 
pesticides