US EPA

1334173 

Journal Article 

Stability and compatibility of etoposide in 0.9% sodium chloride injection in three containers 

Barthes, DM; Rochard, EB; Pouliquen, IJ; Rabouan, SM; Courtois, PY 

1994 

Yes 

American Journal of Hospital Pharmacy
ISSN: 0002-9289 

IPA/95/1065150 

J 

REF 8 

2706-2709 

eng 

IPA COPYRIGHT: ASHP The compatibility of 400 mcg/ml injection of etoposide (Vepeside) in 0.9% sodium chloride injection with glass, polyvinyl chloride (PVC), and polyethylene containers, including leaching of diethylhexyl phthalate (DEHP) from the polyvinyl chloride bags, is reported; samples were stored at 2-6DGC and 22-26DGC for up to 96 h. No color variation occurred during the 96 h study, but precipitation did appear in the glass containers stored at 2-6DGC for 48 h and in all solutions at 72 h. Chemical analysis showed the precipitate to be etoposide. The etoposide concentrations were greater at 22-26DGC than in the containers stored at 2-6DGC. The amount of DEHP leached into the solutions from the PVC bags increased with time and was exaggerated at the higher temperature. It was concluded that etoposide in 0.9% sodium chloride injection was stable in glass or polyethylene containers at 4 or 24DGC for up to 24 h. Etoposide should not be stored in PVC bags because of leaching of DEHP. 

Etoposide; incompatibilities; vehicles; Sodium chloride; etoposide; Polyvinyl chloride; etoposide; Polyethylene; Diethylhexyl phthalate; plasticizers; leaching; Antineoplastic agents; incompatibilities; etoposide(Antineoplastic agents; Vehicles; incompatibilities; Containers; etoposide and containers or vehicles; stability; sodium chloride and etoposide; polyvinyl chloride and etoposide; polyethylene and etoposide; Stability; incompatibilities; Storage; Additives; injections; etoposide; Temperature; Precipitation; Glass; Vepeside; PVC; DEHP