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1334223 
Journal Article 
Compatibility of docetaxel and paclitaxel in intravenous solutions with polyvinyl chloride infusion materials 
Mazzo, DJ; Nguyen-Huu, JJ; Pagniez, S; Denis, P 
1997 
Yes 
American Journal of Health-System Pharmacy
ISSN: 1079-2082
EISSN: 1535-2900 
IPA/97/1124187 
J 
REF 7 
566-569 
eng 
IPA COPYRIGHT: ASHP A study evaluating the extent of leaching of plasticizers from 2 brands of polyvinyl chloride (PVC) containers with docetaxel (Taxotere) and paclitaxel (Taxol) injections is reported; injections were stored for up to 8 h at room temperature and under simulated administration conditions. Docetaxel in polysorbate 80 was diluted to 0.56 and 0.96 mg/ml, initially with 13% ethyl alcohol (ethanol), then to its final concentration with 0.9% sodium chloride or 5% dextrose. Paclitaxel in alcoholic polyoxyl 40 hydrogenated castor oil (Cremophor RH-40) was diluted to 0.3 and 1.2 mg/ml with 0.9% sodium chloride or 5% dextrose. Stability studies were conducted with the commercial drug solutions and with the injection vehicles. Docetaxel and paclitaxel prepared with both sodium chloride and dextrose leached diethylhexyl phthalate (DEHP) from PVC infusion materials when stored for up to 8 h at 20-22DGC or after a 1 h (docetaxel) or a 3 h (paclitaxel) simulated infusion. Paclitaxel leached 2 to 8 times as much DEHP as docetaxel. DEHP leaching increased with time and was independent of the brand of PVC infusion material. 
Docetaxel; incompatibilities; polyvinyl chloride; Paclitaxel; Sodium chloride; diluents; antineoplastic incompatibilities; Dextrose; Alcohols; docetaxel incompatibilities; docetaxel; Diethylhexyl phthalate; leaching; Polyoxyl 40 hydrogenated castor oil; vehicles; paclitaxel incompatibilities; Polysorbate 80; Antineoplastic agents; docetaxel(Antineoplastic agents; paclitaxel(Antineoplastic agents; Stability; plasticizer leaching; Storage; polyvinyl chloride and docetaxel or paclitaxel; docetaxel and polyvinyl chloride; paclitaxel and polyvinyl chloride; Injections; Containers; Concentration; polyvinyl chloride containers; Plasticizers; Plastics; DEHP; Taxol; Taxotere; PVC; Ethanol; Cremophor RH-40