Health & Environmental Research Online (HERO)


Print Feedback Export to File
1334256 
Journal Article 
Sorption of amiodarone to polyvinyl chloride infusion bags and administration sets 
Weir, SJ; Myers, VAS; Bengtson, KD; Ueda, CT 
1985 
Yes 
American Journal of Hospital Pharmacy
ISSN: 0002-9289 
IPA/86/665065 
J 
REF 15 
2679-2683 
English 
4083289 
IPA COPYRIGHT: ASHP The loss of amiodarone hydrochloride (I) from intravenous admixtures to flexible polyvinyl chloride (PVC) infusion bags and IV administration sets was studied. Admixtures containing 600 mcg/ml of I and either 5% dextrose injection or 0.9% sodium chloride injection were stored at room temperature for up to 120 h in glass bottles, flexible PVC bags, or rigid PVC bottles. Samples of I solutions were analyzed by a stability-indicating high performance LC assay. Admixtures containing I and 0.9% sodium chloride injection were not stable; visual incompatibility was evident after 24 h of storage in glass bottles. For admixtures containing I and 5% dextrose injection stored in 50-ml flexible PVC bags, I concentrations decreased by 40% after 120 h of storage. Only 82% of the initial I concentration remained in solutions infused from the glass containers through a 1.8-ml PVC administration set at a rate of 0.5 ml/min for 90 min. The I concentration of solutions in glass bottles or rigid PVC bottles did not decrease appreciably, indicating that drug loss was probably attributable to an effect of the plasticizer, di-2-ethylhexyl phthalate (diethylhexyl phthalate). It was concluded that admixtures containing I and 5% dextrose injection are stable for at least 5 days when stored in glass bottles or rigid PVC bottles at room temperature; however, substantial losses of I can occur from solutions stored in flexible PVC bags or infused through PVC administration sets. 
Diethylhexyl phthalate; incompatibilities; amiodarone IV admixtures; Amiodarone hydrochloride; containers; Dextrose; vehicles; amiodarone; Sodium chloride; amiodarone; Polyvinyl chloride; amiodarone; Glass; amiodarone; Containers; incompatibilities; Surgical supplies; administration sets; polyvinyl chloride; Additives; injections; incompatibilities; Sorption; Stability; incompatibilities; Storage; amiodarone hydrochloride and glass or polyvinyl chloride; IV admixtures; glass and amiodarone hydrochloride; polyvinyl chloride and amiodarone hydrochloride; incompatibilities; Vasodilating agents; amiodarone hydrochloride(Vasodilating agents; Concentration; Plasticizers; PVC; Di-2-ethylhexyl phthalate