US EPA

1334259 

Journal Article 

Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous cyclosporine solution 

Venkataramanan, R; Burckart, GJ; Ptachcinski, RJ; Blaha, R; Brady, JE; Et al 

1986 

Yes 

American Journal of Hospital Pharmacy
ISSN: 0002-9289 

AMER SOC HEALTH-SYSTEM PHARMACISTS 

BETHESDA 

IPA/87/717056 

J 

REF 15 

2800-2802 

English 

3799618 

10.1093/ajhp/43.11.2800 

WOS:A1986E849700026 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023030973&doi=10.1093%2fajhp%2f43.11.2800&partnerID=40&md5=7bdd00d0ae3f961b89347d2ef83eb7e0
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IPA COPYRIGHT: ASHP The release of diethylhexyl phthalate (DEHP; I) into intravenous cyclosporine (II) solutions stored in plastic polyvinyl chloride bags was studied. Intravenous II solutions were prepared in an all-glass system and stored in plastic bags. Four samples were obtained at different time intervals, and the I content was analyzed by gas chromatography. The amount that was leached into solutions stored in plastic bags increased as storage time increased. In 48 h, nearly 33 mg of I had leached into the solution. It was concluded that intravenous II solutions should be prepared in glass containers to minimize patient exposure to I. If plastic bags are used for preparing II solutions, the solutions must be used immediately after preparation. 

Cyclosporine; incompatibilities; PVC containers; Diethylhexyl phthalate; contamination; cyclosporine; Polyvinyl chloride; cyclosporine; cyclosporine and polyvinyl chloride; IV bags; polyvinyl chloride and cyclosporine; Immunosuppressive agents; incompatibilities; cyclosporine(Immunosuppressive agents; Containers; incompatibilities; Plasticizers; incompatibilities; Leaching; PVC containers; Chromatography; leaching; Storage; Injections; IV; cyclosporine; Stability; DEHP