Stability of three cytotoxic drug infusions in the Graseby 9000 ambulatory infusion pump | Health & Environmental Research Online (HERO)

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HERO ID

1334456

Reference Type

Journal Article

Title

Stability of three cytotoxic drug infusions in the Graseby 9000 ambulatory infusion pump

Author(s)

Priston, MJ; Sewell, GJ

Year

1998

Is Peer Reviewed?

Yes

Journal

Journal of Oncology Pharmacy Practice
ISSN: 1078-1552

Report Number

IPA/99/1182228

Volume

Oncol

Issue

REF 13

Page Numbers

143-149

Language

English

DOI

10.1177/107815529800400302

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84990386119&doi=10.1177%2f107815529800400302&partnerID=40&md5=d6f884fc57ef9e788038417595ad9c92
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Abstract

IPA COPYRIGHT: ASHP A study of the stability of 3 cytotoxic infusions in the Graseby 9000 ambulatory pump under both refrigerated storage and in-use conditions is presented; the infusions studied were doxorubicin 2 mg/ml plus vincristine 0.2 mg/ml, ifosfamide 20 mg/ml plus mesna 20 mg/ml, and etoposide 0.5 mg/ml. Both the doxorubicin plus vincristine and the ifosfamide plus mesna infusions were physically and chemically stable in Graseby 9000 medication cassettes for 14 days at 8DGC and for 7 days at 37DGC. The etoposide infusion caused significant leaching of diethylhexyl phthalate plasticizer from the Graseby cassette; in addition, one of the infusion cassettes stored at 8DGC exhibited precipitation of etoposide by day 10.

Keywords

Doxorubicin; injections; stability; Ifosfamide; Vincristine; Etoposide; Mesna; Diethylhexyl phthalate; plasticizers; infusion devices; Antineoplastic agents; infusion pumps; doxorubicin(Antineoplastic agents); Storage; ifosfamide(Antineoplastic agents); Temperature; vincristine(Antineoplastic agents); etoposide(Antineoplastic agents); Cytoprotectants; stability; Devices