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Citation
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HERO ID
1334456
Reference Type
Journal Article
Title
Stability of three cytotoxic drug infusions in the Graseby 9000 ambulatory infusion pump
Author(s)
Priston, MJ; Sewell, GJ
Year
1998
Is Peer Reviewed?
Yes
Journal
Journal of Oncology Pharmacy Practice
ISSN:
1078-1552
Report Number
IPA/99/1182228
Volume
Oncol
Issue
REF 13
Page Numbers
143-149
Language
English
DOI
10.1177/107815529800400302
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84990386119&doi=10.1177%2f107815529800400302&partnerID=40&md5=d6f884fc57ef9e788038417595ad9c92
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Abstract
IPA COPYRIGHT: ASHP A study of the stability of 3 cytotoxic infusions in the Graseby 9000 ambulatory pump under both refrigerated storage and in-use conditions is presented; the infusions studied were doxorubicin 2 mg/ml plus vincristine 0.2 mg/ml, ifosfamide 20 mg/ml plus mesna 20 mg/ml, and etoposide 0.5 mg/ml. Both the doxorubicin plus vincristine and the ifosfamide plus mesna infusions were physically and chemically stable in Graseby 9000 medication cassettes for 14 days at 8DGC and for 7 days at 37DGC. The etoposide infusion caused significant leaching of diethylhexyl phthalate plasticizer from the Graseby cassette; in addition, one of the infusion cassettes stored at 8DGC exhibited precipitation of etoposide by day 10.
Keywords
Doxorubicin
;
injections
;
stability
;
Ifosfamide
;
Vincristine
;
Etoposide
;
Mesna
;
Diethylhexyl phthalate
;
plasticizers
;
infusion devices
;
Antineoplastic agents
;
infusion pumps
;
doxorubicin(Antineoplastic agents)
;
Storage
;
ifosfamide(Antineoplastic agents)
;
Temperature
;
vincristine(Antineoplastic agents)
;
etoposide(Antineoplastic agents)
;
Cytoprotectants
;
stability
;
Devices
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