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1334456 
Journal Article 
Stability of three cytotoxic drug infusions in the Graseby 9000 ambulatory infusion pump 
Priston, MJ; Sewell, GJ 
1998 
Yes 
Journal of Oncology Pharmacy Practice
ISSN: 1078-1552 
IPA/99/1182228 
Oncol 
REF 13 
143-149 
English 
IPA COPYRIGHT: ASHP A study of the stability of 3 cytotoxic infusions in the Graseby 9000 ambulatory pump under both refrigerated storage and in-use conditions is presented; the infusions studied were doxorubicin 2 mg/ml plus vincristine 0.2 mg/ml, ifosfamide 20 mg/ml plus mesna 20 mg/ml, and etoposide 0.5 mg/ml. Both the doxorubicin plus vincristine and the ifosfamide plus mesna infusions were physically and chemically stable in Graseby 9000 medication cassettes for 14 days at 8DGC and for 7 days at 37DGC. The etoposide infusion caused significant leaching of diethylhexyl phthalate plasticizer from the Graseby cassette; in addition, one of the infusion cassettes stored at 8DGC exhibited precipitation of etoposide by day 10. 
Doxorubicin; injections; stability; Ifosfamide; Vincristine; Etoposide; Mesna; Diethylhexyl phthalate; plasticizers; infusion devices; Antineoplastic agents; infusion pumps; doxorubicin(Antineoplastic agents); Storage; ifosfamide(Antineoplastic agents); Temperature; vincristine(Antineoplastic agents); etoposide(Antineoplastic agents); Cytoprotectants; stability; Devices