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1400792 
Journal Article 
Hormesis: Its impact on medicine and health 
Calabrese, E; Iavicoli, I; Calabrese, V 
2012 
Yes 
Human & Experimental Toxicology
ISSN: 0960-3271
EISSN: 1477-0903 
32 
2 
120-152 
English 
23060412 
WOS:000313811600002 
This article offers a broad assessment of the hormetic dose response and its relevance to biomedical researchers, physicians, the pharmaceutical industry, and public health scientists. This article contains a series of 61 questions followed by relatively brief but referenced responses that provides support for the conclusion that hormesis is a reproducible phenomenon, commonly observed, with a frequency far greater than other dose-response models such as the threshold and linear nonthreshold dose-response models. The article provides a detailed background information on the historical foundations of hormesis, its quantitative features, mechanistic foundations, as well as how hormesis is currently being used within medicine and identifying how this concept could be further applied in the development of new therapeutic advances and in improved public health practices. 
Hormesis; hormetic; biphasic; U-shaped; J-shaped; adaptive response; personalized medicine