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1409 
Journal Article 
Localization of metabolic activation and deactivation systems in the lung: significance to the pulmonary toxicity of xenobiotics 
Minchin, RF; Boyd, MR 
1983 
Yes 
Annual Review of Pharmacology and Toxicology
ISSN: 0362-1642
EISSN: 1545-4304 
23 
217-238 
English 
The lung is a complex organ with a great deal of histological and biochemical heterogeneity. The distribution of systems responsible for the metabolic activation of lung toxins and/or their detoxification can vary substantially from one cell-type to another. This suggests that localized damage by xenobiotics requiring metabolic activation can, at least in part, be attributed to the localization of such systems. Recent advances in the isolation of different lung cell-types in reasonably pure fractions have allowed for investigation of the metabolic capabilities of some individual cell-types. A more complete understanding of the mechanisms of pulmonary metabolic activation and deactivation of toxic chemicals and drugs may contribute to our knowledge of the underlying causes of various pathological processes such as cellular necrosis, fibrosis, emphysema, and cancer, any of which may arise from the interaction of chemical toxins with lung tissue. We hope that this review has drawn attention to some of the newer and less understood aspects of pulmonary activation/deactivation of toxic drugs and chemicals.