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1441424 
Journal Article 
Renal tubular cell regeneration, cell proliferation and chronic nephrotoxicity in the goldfish Carassius auratus following exposure to a single sublethal dose of hexachlorobutadiene 
Reimschuessel, R; Bennett, RO; May, EB; Lipsky, MM 
1990 
Yes 
Diseases of Aquatic Organisms
ISSN: 0177-5103
EISSN: 1616-1580 
BIOSIS/90/28785 
8 
3 
211-224 
English 
WOS:A1990DU20500007 
Regeneration of the epithelium following injury is a vital process in many organs of both mammals and fish. An understanding of this response is essential when evaluating the impact of xenobiotics on tissues such as the kidney. The present studies demonstrate regeneration of the goldfish Carassius auratus renal proximal tubular epithelium following toxicant induced injury (hexachlorobutadiene, HCBD 500 mg kg-1). HCBD-induced vacuolation and necrosis of the proximal tubular epithelium were observed with 24 h and continued for 10 wk following the single intraperitoneal injection. A flattened, basophilic regenerating epithelium was observed along the intact basement membrane 1 wk post HCBD-treatment. In the following weeks, as the regenerating epithelial cells differentiated, they developed vacuoles and became necrotic. In addition, 2 wk after exposure, newly formed nephrons developed from basophilic cell clusters adjacent to collecting ducts. Ten weeks following the single [truncated]. 
Cytology and Cytochemistry-Animal; Radiation-Radiation and Isotope Techniques; Biochemical Studies-General; Anatomy and Histology; Pathology; Digestive System-Pathology; Toxicology-General; Developmental Biology-Embryology-Morphogenesis; Osteichthyes