US EPA

1498795 

Journal Article 

Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats 

Hesterberg, TW; Miller, WC; Mcconnell, EE; Chevalier, J; Hadley, JG; Bernstein, DM; Thevenaz, P; Anderson, R 

1993 

Yes 

Fundamental and Applied Toxicology
ISSN: 0272-0590
EISSN: 1095-6832 

ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS 

SAN DIEGO 

BIOSIS/93/22278 

20 

4 

464-476 

English 

8390950 

10.1006/faat.1993.1057 

WOS:A1993LB92500007 

BIOSIS COPYRIGHT: BIOL ABS. This study was initiated to determine the chronic biological effects in Fisher 344 rats of inhaled size-separated respirable fractions of fibrous glass (FG) having compositions representative of common building insulation wools. Rats were exposed using nose-only inhalation chambers, 6 hr/day, 5 days/week, for 24 months to three concentrations (3, 16, and 30 mg/m3) of two different compositions of FG (designated MMVF 10 and MMVF 11), or to filtered air (negative control). Fibrous glass findings were compared to those from a concurrent inhalation study of chrysotile asbestos and refractory ceramic fiber (RCF). The FGs used in this study were size selected to be largely respirable in the rat and the aerosol generation technique did not alter the dimensions of the fibers. Interim euthanizations took place at 3- to 6-month intervals to monitor progression of pulmonary changes. Fibers were recovered from digested lung tissue for determination of changes in fiber number and mo 

Biochemical Studies-Minerals; Respiratory System-Pathology; Toxicology-General; Toxicology-Environmental and Industrial Toxicology; Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis; Public Health: Environmental Health-Air; Muridae