US EPA

1512674 

Journal Article 

Differences in nociceptive behavioral performance between C57BL/6J, 129S6/SvEv, B6 129 F1 and NMRI mice 

Leo, S; Straetemans, R; D'Hooge, R; Meert, T 

2008 

Yes 

Behavioural Brain Research
ISSN: 0166-4328
EISSN: 1872-7549 

190 

2 

233-242 

English 

18420287 

10.1016/j.bbr.2008.03.001 

WOS:000256182800011 

http://://WOS:000256182800011
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The interpretation of knockout and transgenic mouse studies in pain research critically depends on detailed knowledge of the performance profile of the background strains. Pain-related behavior was compared between four relevant mouse strains (C57BL/6J, 129S6/SvEv, B6 129 F1 and NMRI mice of both sexes) using an extended test battery that included an unusual variety of assays for thermal and mechanical acute nociception, and inflammatory and neuropathic pain. Strain- and gender-dependent differences were demonstrated in many of these nociceptive assays. Particularly, C57BL and 129 mice, which serve as the default genetic backgrounds for experiments in genetically altered mice, display quite different patterns of nociceptive performance. Compared to C57BL/6J mice, 129S6/SvEv animals are less sensitive to inflammatory pain conditions (thermal sensitivity after carrageenan subplantar injection; flinch behavior after formalin injection), while the opposite is observed in the neuropathic pain condition and the visceral pain model. These data may be of special interest for genetic studies, where issues related to the background phenotype may confound their interpretation. 

genetic background strains; nociception; pain; strain and gender differences; knockout studies