Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

1512779

Reference Type

Journal Article

Title

Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II

Author(s)

Macqueen, G; Marshall, J; Perdue, M; Siegel, S; Bienenstock, J

Year

1989

Is Peer Reviewed?

Journal

Science
ISSN: 0036-8075
EISSN: 1095-9203

Volume

243

Issue

4887

Page Numbers

83-85

Language

English

PMID

2911721

DOI

10.1126/science.2911721

Web of Science Id

WOS:A1989R646900036

URL

http://www.sciencemag.org/cgi/doi/10.1126/science.2911721
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Abstract

Antigen (egg albumin) injections, which stimulate mucosal mast cells to secrete mediators, were paired with an audiovisual cue. After reexposure to the audiovisual cue, a mediator (rat mast cell protease II) was measured with a sensitive and specific assay. Animals reexposed to only the audiovisual cue released a quantity of protease not significantly different from animals reexposed to both the cue and the antigen; these groups released significantly more protease than animals that had received the cue and antigen in a noncontingent manner. The results support a role for the central nervous system as a functional effector of mast cell function in the allergic state.

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