Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease | Health & Environmental Research Online (HERO)

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HERO ID

1513853

Reference Type

Journal Article

Title

Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease

Author(s)

Wang, T; Sun, XL

Year

2012

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Journal

Shengwu Huaxue yu Shengwu Wuli Jinzhan / Progress in Biochemistry and Biophysics
ISSN: 1000-3282

Volume

Issue

Page Numbers

709-714

DOI

10.3724/sp.j.1206.2012.00217

URL

http://pub.chinasciencejournal.com/article/getArticleRedirect.action?doiCode=10.3724/SP.J.1206.2012.00217
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Abstract

A beta is the major components of amyloid plaque deposition in the brain, and is considered to be the initiating factor for the pathogenesis of Alzheimer's disease(AD). beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is one of the important enzymes in the A beta production. The process of maturation and expression of BACE1 is regulated by a variety of factors. Some of the pathological changes of early onset of AD such as ischemia, hypoxia, inflammation and stress are considered to be BACE1 related. Many BACE1 and A beta related cytokines in the fluids may become potential biomarkers, which would provide ideas for early clinical diagnosis of AD.

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