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1532141 
Journal Article 
Treatment strategies for diabetic patients suffering from erectile dysfunction 
Chen, Yun; Dai, Y; Wang, Run 
2008 
1 
Expert Opinion on Pharmacotherapy
ISSN: 1465-6566
EISSN: 1744-7666 
9 
2 
257-266 
18201148 
WOS:000252878400008 
Erectile dysfunction is a common complication of diabetes.
Clinical practice has no treatment modality specifically designed for the difficult to treat
diabetic erectile dysfunction due to the multifactorial and complex pathophysiology of
development. PDE type 5 inhibitors are the first-line treatment option. Non-responders should
have total and free testosterone checked and testosterone replacement is recommended for
hypogonadal patients. For patients who cannot take PDE type 5 inhibitors, or are proven non-
responders, the vacuum constriction device continues to serve as a major treatment option.
Intracavernosal injection is the most effective medical therapy for diabetic erectile dysfunction
despite its high dropout rate. Use of the Medicated Urethral System for Erection to overcome the
disadvantages of needle injection is disappointing due to lack of effectiveness. Penile
prosthesis will continue to play an important role in diabetic patients with severe erectile
dysfunction in coming years. 
diabetes; erectile dysfunction; treatment