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HERO ID
1543217
Reference Type
Journal Article
Subtype
Review
Title
Recent advances in the study on resveratrol
Author(s)
Nakata, R; Takahashi, S; Inoue, H
Year
2012
Is Peer Reviewed?
Yes
Journal
Biological and Pharmaceutical Bulletin
ISSN:
0918-6158
EISSN:
1347-5215
Volume
35
Issue
3
Page Numbers
273-279
Language
English
PMID
22382311
Web of Science Id
WOS:000300925200001
URL
http://www.jstage.jst.go.jp/article/bpb/35/3/35_3_273/_article
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Abstract
Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.
Keywords
resveratrol; cyclooxygenase; peroxisome proliferator-activated receptor; endothelial nitric oxide synthase; silent mating type information regulation 2 homolog 1
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