Gastroprotective Effect of Cordia Myxa L. Fruit Extract against Indomethacin-Induced Gastric Ulceration in Rats | Health & Environmental Research Online (HERO)

HERO ID

1547458

Reference Type

Journal Article

Title

Gastroprotective Effect of Cordia Myxa L. Fruit Extract against Indomethacin-Induced Gastric Ulceration in Rats

Author(s)

Inas, ZAA; Hala, AHK; Gehan, HH

Year

2011

Is Peer Reviewed?

1

Journal

Life Science Journal
ISSN: 1097-8135

Volume

8

Issue

3

Page Numbers

433-445

Web of Science Id

WOS:000303523200067

Abstract

Gastric ulcer is one of the most serious diseases in the
world. Although there are many drugs used for the treatment of gastric ulcer, most of these
produce several adverse reactions. This study investigated the protective effects of Assyrian
plum (Cordia myxa L.) fruit extract (CME) against indomethacin-induced gastric ulcer in rats.
Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg(-
1) b.wt.). CME was administered orally at a dose of 125 mg/kg b.wt. and ranitidine (RAN), a
reference drug, at a dose of 50 mg/kg b.wt. two weeks prior to indomethacin injection.
Pretreatment with CME produced significant reduction in gastric mucosal lesions (U. I.),
malondialdehyde (MDA), and serum tumor necrosis factor (TNF alpha) associated with significant
increase in gastric juice mucin content and gastric mucosal catalase (CAT), nitric oxide (NO),
and prostaglandin E-2 (PGE(2)) levels. A similar increase in mucin content, NO and PGE(2) was not
observed with RAN although it generated a preventive index of 75.9%. RAN significantly increased
pH value and decreased pepcin activity, and gastric juice free and total acidity. Histological
studies of stomach mucosa confirmed these results. Stomach of rats administrated with RAN showed
leukocytic infiltration in submucosal layer. Meanwhile, stomach of rats administrated CME either
alone or with RAN showed no histopathological changes. CME can protect indometacin-induced
gastric ulceration due to its antioxidative and mucin enhancing properties. The protection
afforded by co-administration of CME and RAN was found to be better than that of RAN alone.
Results of the present study suggest that RAN should be used together with CME for better
gastroprotective effect as well as to reduce H-2 antagonists drugs adverse effects. [Inas, Z.A.
Abdallah, Hala, A.H. Khattab and Gehan, H. Heeba. Gastroprotective Effect of Cordia Myxa L. Fruit
Extract against Indomethacin-Induced Gastric Ulceration in Rats] Life Science Journal, 2011; 8
(3): 433-445] (ISSN: 1097-8135). http://www.lifesciencesite.com.

Keywords

Cordia myxa Extract; Gastroprotective; Indomethacin; Ranitidine