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1547816 
Journal Article 
Fitting into the Harsh Reality: Regulation of Iron-deficiency Responses in Dicotyledonous Plants 
Ivanov, R; Brumbarova, T; Bauer, P 
2012 
1 
Molecular Plant
ISSN: 1674-2052
EISSN: 1752-9867 
5 
1 
27-42 
21873619 
WOS:000299347400003 
Iron is an essential element for life on Earth and its
shortage, or excess, in the living organism may lead to severe health disorders. Plants serve as
the primary source of dietary iron and improving crop iron content is an important step towards a
better public health. Our review focuses on the control of iron acquisition in dicotyledonous
plants and monocots that apply a reduction-based strategy in order to mobilize and import iron
from the rhizosphere. Achieving a balance between shortage and excess of iron requires a tight
regulation of the activity of the iron uptake system. A number of studies, ranging from single
gene characterization to systems biology analyses, have led to the rapid expansion of our
knowledge on iron uptake in recent years. Here, we summarize the novel insights into the
regulation of iron acquisition and internal mobilization from intracellular stores. We present a
detailed view of the main known regulatory networks defined by the Arabidopsis regulators FIT and
POPEYE (PYE). Additionally, we analyze the root and leaf iron-responsive regulatory networks,
revealing novel potential gene interactions and reliable iron-deficiency marker genes. We discuss
perspectives and open questions with regard to iron sensing and post-translational regulation. 
Iron uptake; gene expression; transcription factors; post-transcriptional regulation