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1549870 
Journal Article 
Redox-active radical scavenging nanomaterials 
Karakoti, A; Singh, S; Dowding, JM; Seal, S; Self, WT 
2010 
Yes 
Chemical Society Reviews
ISSN: 0306-0012
EISSN: 1460-4744 
39 
11 
4422-4432 
20717560 
WOS:000283141300028 
Reactive oxygen and nitrogen species play a critical role
in many degenerative diseases and in aging. Nanomaterials, especially modified fullerenes and
cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage
caused by increased reactive oxygen or nitrogen species, likely through their direct reaction
with superoxide radical, since each of these materials has been shown to act as effective
superoxide dismutase mimetics in vitro. This critical review discusses the chemistry of these
nanomaterials and the context in which their radical scavenging activities have been studied in
biological model systems. Current studies are focused on determining the uptake, metabolism,
distribution, toxicity and fate of these nanomaterials in cell and animal model systems.
Ultimately if shown to be safe, these nanomaterials have the potential to be used to reduce the
damaging effects of radicals in biological systems (101 references).