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1557139 
Journal Article 
Role of antioxidants in the skin: Anti-aging effects 
Masaki, H 
2010 
Yes 
Journal of Dermatological Science
ISSN: 0923-1811 
58 
2 
85-90 
20399614 
WOS:000277543100001 
Intracellular and extracellular oxidative stress initiated
by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and
atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually
discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent
symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS
generation and ROS elimination in the body are summarized. The effects of ROS generated in the
skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of
representative antioxidants on the skin are summarized with a focus on skin aging. (c) 2010
Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights
reserved. 
Antioxidant; ROS; Oxidative stress; UV