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1558636 
Journal Article 
Factors in the pathophysiology of the liver ischemia-reperfusion injury 
Montalvo-Jave, EE; Escalante-Tattersfield, T; Ortega-Salgado, JA; Pina, E; Geller, DA 
2008 
Yes 
Journal of Surgical Research
ISSN: 0022-4804
EISSN: 1095-8673 
147 
1 
153-159 
17707862 
WOS:000255668500023 
Hepatic ischemia-reperfusion injury is commonplace in liver
surgery, particularly in hepatic transplantation, hepatic resection, and trauma. The signaling
events contributing to local hepatocellular damage are diverse and complex and involve the
interaction between hepatocytes, sinusoidal endothelial cells, Kupffer cells, as well as
infiltrating neutrophils, macrophages, and platelets. Signaling mediators include cytokines,
reactive oxygen and nitrogen species, calcium, complement, and several transcription factors. The
purpose of this review article was to summarize the factors that contribute to the
pathophysiology of hepatic ischemia-reperfusion injury. (C) 2008 Elsevier Inc. All rights
reserved. 
liver; ischemia-reperfusion; IR injury; nitric oxide; NO; iNOS; adenosine; cytokines; endothelial and Kupffer cells; ROS