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1561929 
Journal Article 
Ginkgo biloba Extract Attenuates Hyperalgesia in a Rat Model of Vincristine-Induced Peripheral Neuropathy 
Park, H; Lee, H; Kim, Y; Lee, J; Jeon, J; Park, C; Moon, D 
2012 
Yes 
Anesthesia and Analgesia
ISSN: 0003-2999
EISSN: 1526-7598 
115 
5 
1228-1233 
23011564 
WOS:000310762100032 
BACKGROUND: Chemotherapy-induced peripheral neuropathy is a
common, dose-limiting side effect of cancer chemotherapeutic drugs. Hyperalgesia is a common
component of neuropathic pain. Ginkgo biloba extract (GBE) is an oriental herbal medicine that
has various pharmacological actions. In this study, we evaluated the effects of oral GBE on
hyperalgesia in a rat model of vincristine-induced neuropathy. METHODS: Male Sprague-Dawley rats
(200-250 g) were injected intraperitoneally with vincristine or saline (0.1 mg/kg/d) using a 5-
day-on, 2-day-off schedule over 12 days. All the behavioral tests for mechanical, cold, and heat
hyperalgesia were conducted before the daily injection during the course of vincristine
treatment. Rats that developed hyperalgesia 14 days after vincristine injection were randomly
assigned into 4 groups. Distilled water and GBE (50, 100, and 150 mg/kg) were administered,
respectively, to the individual groups. We examined the hyperalgesia at preadministration and at
15, 30, 60, 90, 120, 150, and 180 minutes after oral drug administration. RESULTS: Saline
injection did not have any significant effect on mechanical, cold, and heat hyperalgesia.
Vincristine injection produced mechanical and cold hyperalgesia. For the GBE groups, the paw
withdrawal threshold to mechanical stimuli was significantly increased and withdrawal frequency
to cold stimuli was significantly reduced versus the control group dose-dependently (P < 0.05).
CONCLUSIONS: This study demonstrates that oral administration of GBE is associated with a dose-
dependent antihyperalgesic effect on mechanical and cold stimuli in a rat model of vincristine-
induced neuropathy. (Anesth Analg 2012;115:1228-33)