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1562229 
Journal Article 
The role of caveolin-1 in human breast cancer 
Patani, N; Martin, L; Reis-Filho, JS; Dowsett, M 
2012 
Yes 
Breast Cancer Research and Treatment
ISSN: 0167-6806
EISSN: 1573-7217 
131 
1 
1-15 
21901387 
WOS:000298006300001 
Caveolin-1 is the essential constituent protein of
specialised plasma membrane invaginations called caveolae. The unique topology of caveolin-1
facilitates the role of caveolae as molecular hubs, integrating the activity of a multitude of
signalling molecules. Despite improvements in our understanding of caveolin-1 interactions and
the function of caveolae, the relationship between dysfunctional caveolin-1 and tumourigenesis
remains contentious. Perhaps most intriguing has been the demonstration of both oncogenic and
tumour suppressor function within particular tumour types, including breast cancer. In this
review, the biological and clinical relevance of caveolin-1 in human breast cancer are
considered. Evidence is systematically presented for the potential tumour suppressor and
oncogenic functions of caveolin-1. Specific reference is made to interactions between caveolin-1
and signalling pathways in the clinical and biological subtypes of breast cancer. Areas of
controversy are discussed and technical considerations are highlighted. Translational
implications and potential for specific therapeutic manipulation of caveolin-1 are evaluated in
the context of evidence from in vitro and in vivo studies. 
Caveolin-1; Breast cancer; Tumour suppressor gene; Oncogene; Evidence