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1562576 
Journal Article 
Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease 
Penumathsa, SV; Maulik, N 
2009 
1 
Canadian Journal of Physiology and Pharmacology
ISSN: 0008-4212
EISSN: 1205-7541 
87 
4 
275-286 
19370081 
WOS:000265606000004 
The inverse association between alcohol intake and coronary
heart disease has been consistently reported in cross-culture, case-control, and cohort studies.
Over the past couple of decades, however, many studies have explained promising health benefits
associated with wine consumption. Some studies suggest that red wine is more cardioprotective
than white wine, possibly due to the increased content of flavanoid antioxidants found in red
wine. Several experimental studies, including ours, support the evidence that these beneficial
effects are due to resveratrol, the polyphenolic compound present in red wine. Many studies have
provided evidence that resveratrol possesses antioxidant and antiapoptotic effects apart from
activation of longevity proteins (such as SIRT-1). We have recently reported the angiogenic,
antihypercholesterolemic, and antidiabetic effects of resveratrol and the mechanisms involved in
reduced ventricular remodeling and increased cardiac functions. We have also shown different
strategic target molecules involved in resveratrol-mediated cardioprotection. Therefore, this
review discusses the potential effect of resveratrol and the mechanisms involved in resveratrol-
mediated cardioprotection during myocardial infarction, hypercholesterolemia, and diabetes
rendering its beneficial effects during health and disease. 
resveratrol; VEGF; angiopoietin-1; Trx-1; HO-1; Cav-1/eNOS; angiogenesis; hypercholesterolemia; diabetes