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1567329 
Book/Book Chapter 
THE ROLE OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE IN MODULATION OF OXYGEN COST OF MYOCARDIAL WORK BY ENDOGENOUS NO 
Shimanskaya, T; Goshovska, Y; Sagach, V 
2010 
Recent Advances in Biology and Biomedicine 
313-317 
WOS:000277025900040 
In experiments of isolated hearts it had been shown that NO
produced by NOS in physiological concentration is an effective inhibitor of mPTP opening and a
modulator of oxygen cost of myocardial work. Impaired synthesis and lack of NO may be a reason of
increased oxygen cost of myocardial work during ischemia-reperfusion. Blockade of mPTP opening
abolishes effects of NO on oxygen cost of myocardial work. 
nitric oxide; mitochondrial permeability transition; isolated heart; oxygen cost of myocardial work