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1567722 
Journal Article 
Morphogenetic Movement of Cells in Embryogenesis of Drosophila melanogaster: Mechanism and Genetic Control 
Simonova, OB; Burdina, NV 
2009 
1 
Russian Journal of Developmental Biology
ISSN: 1062-3604
EISSN: 1608-3326 
40 
5 
283-299 
WOS:000270817200003 
Morphogenetic movement of cells is of significant
importance in embryogenesis. It is necessary to identify the final position and configuration of
the embryo's tissues and share the positional information in differentiation. The healing of
tissular injuries happens in the adult organism due to the cell layers' movement, and the
directed macrophages migration to the nidus of infection assists the neutralization of
inflammatory processes. Owing to the good level of knowledge, the fruit fly D. melanogaster is a
perfect model object for the study of morphogenetic events in embryogenesis in connection with
the cells movement. The description of Drosophila embryogenesis, mechanisms of ventral furrow
formation, elongation of the germ band, and its contraction accompanied by dorsal closure was
given. During these processes the movement of epithelial cells and the entire epithelial strata
happens. The information about the genetic regulation of morphogenetic movement of D.
melanogaster taking into consideration the scale of evolutionary conservatism of the cascades of
the main signal, which control these processes in vertebrates, is presented. 
embryogenesis; ventral furrow; germ band; amnioserose; trachea; adherent junctions; cellular intercalation; cells polarization; D. melanogaster