US EPA

1568936 

Journal Article 

Effects of Siqi decoction on concentration of nitric oxide and activity of nitiric oxide synthase in blood serum of rats with Myocardial Ischemia 

Su Yan-bin; Li Zheng-qiang; Su Yan-wen; Zhang Fen-rong 

2008 

Yes 

Chemical Research in Chinese Universities
ISSN: 1005-9040 

24 

1 

65-68 

WOS:000252973200014 

To study the effects of Siqi decoction on rats with
Myocardial Ischemia, the model of Myocardium Ischemia was made for the Wistar rats cured with
posterior pituitary injection through vein in tail. Siqi decoction, Diaoxinxuekang(DK) and
Fufangdanshenpian(FD), the latter two drugs of which were effective TCM drugs of anti-Myocardial
Ischemia at present, were administrated to the rats with Myocardium Ischemia for 5 days to
compare the effect of anti-Myocardium Ischemia as reference drugs by measuring the changes of NO
concentration and activity of NOS in the rat blood serum with Myocardial Ischemia. There was a
remarkable increase in the NO concentration and activity of NOS in serum in Siqi decoction groups
compared with those in control group(p<0.05). The results of the prevention group in experiment
of Siqi decoction are better than those of the cure group. Siqi decoction was really fit for
Myocardium Ischemia via increasing NO concentration by stimulating the activity of NOS in serum.
The effect of Siqi decoction against Myocardium Ischemia in preventive group is better than the
curative that of Siqi decoction in the curative group. 

Siqi decoction; Myocardial Ischemia; posterior pituitary; nitric oxide(NO); nitric oxide synthase(NOS)