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HERO ID
1570458
Reference Type
Journal Article
Title
Multiple sclerosis: An immune or neurodegenerative disorder?
Author(s)
Trapp, BD; Nave, KA
Year
2008
Is Peer Reviewed?
Yes
Journal
Annual Review of Neuroscience
ISSN:
0147-006X
EISSN:
1545-4126
Book Title
Annual Review of Neuroscience
Volume
31
Page Numbers
247-269
PMID
18558855
DOI
10.1146/annurev.neuro.30.051606.094313
Web of Science Id
WOS:000257992200011
Abstract
Multiple sclerosis (MS) is an inflammatory-mediated
demyelinating disease of the human central nervous system. The clinical disease course is
variable, usually starts with reversible episodes of neurological disability in the third or
fourth decade of life, and transforms into a disease of continuous and irreversible neurological
decline by the sixth or seventh decade. We review data that support neurodegeneration as the
major cause of irreversible neurological disability in MS patients. We question whether
inflammatory demyelination is primary or secondary in the disease process and discuss the
challenges of elucidating the cause of MS and developing therapies that will delay or prevent the
irreversible and progressive neurological decline that most MS patients endure.
Keywords
myelin; demyelination; axonal degeneration; brain atrophy; cortical pathology; axon-glial interactions
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