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1571929 
Journal Article 
Resveratrol in cardiovascular disease: what is known from current research? 
Wang, H; Yang, Y; Qian, H; Zhang, Q; Xu, Hui; Li, J 
2012 
Yes 
Heart Failure Reviews
ISSN: 1382-4147
EISSN: 1573-7322 
17 
3 
437-448 
21688187 
WOS:000302746600009 
Resveratrol is a well-known antioxidant that exists in
grape skin/seed, red wine, and the root of Polygonum cuspidatum, a traditional Chinese and
Japanese medicinal material. Studies have found that resveratrol has many interesting properties,
including anti-carcinogenic properties, anti-microbial and antiviral effects, the ability to
reverse dyslipidemia and obesity, the ability to attenuate hyperglycemia and hyperinsulinemia,
and the ability to protect endothelial function. Heart failure is the final consequence of the
majority of cardiovascular diseases, and resveratrol has been shown to directly attenuate heart
contraction. The cardiovascular protective capacities of resveratrol are associated with multiple
molecular targets and may lead to the development of novel therapeutic strategies for
atherosclerosis, ischemia/reperfusion, metabolic syndrome, and heart failure. This article will
mainly review recently published basic researches about the protective cardiovascular effects of
resveratrol because these results may lead to the development of new clinical therapeutics in
patients. 
Resveratrol; Antioxidant; Cardiovascular disease; Sirtuin type 1; Adenosine monophosphate-activated protein kinase