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1573062 
Journal Article 
Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults 
Wong, RHX; Howe, PRC; Coates, AM; Buckley, JD; Berry, NM 
2013 
1 
Journal of Hypertension
ISSN: 0263-6352
EISSN: 1473-5598 
31 
1 
192-200 
23221935 
WOS:000312211400028 
Background: Heart health benefits have been attributed to
regular consumption of oats. Preclinical evidence suggests that a wild green oat extract (WGOE)
may improve vasodilator function, but this is yet to be evaluated in humans. Objective: To
determine whether regular daily consumption of WGOE can influence vasodilator function in
systemic and cerebral arteries. Methods: Thirty-seven healthy older adults (>60 years) completed
a 24-week randomized, double-blind, placebo-controlled two-way crossover dietary intervention
with 1500 mg/day of encapsulated WGOE or placebo. All assessments were conducted at the end of
each 12-week intervention arm, after participants had fasted for at least 4 h and at least 18 h
after they had taken their last dose of supplement. Flow-mediated dilatation (FMD) of the
brachial artery and hypercapnia-induced increases of blood flow in the middle cerebral artery
were used to measure systemic and cerebral vasodilator responsiveness (CVR), respectively.
Results: Compared with placebo, WGOE supplementation increased CVR and FMD to a similar extent
(42 and 41%, respectively, P<0.01 for both). The improvements in CVR and FMD were not correlated.
Resting blood pressure did not alter with supplementation. Dose and treatment duration were well
tolerated by participants. Conclusion: WGOE supplementation can improve vasodilator function in
systemic and cerebral arteries, suggesting a potential role in the maintenance of cardiovascular
health. 
avenanthramides; Avena sativa; bioactive nutrients; cerebrovascular responsiveness; flow-mediated dilatation; wild green oats