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1574367 
Journal Article 
Review 
Molecular Mechanisms of IFN-gamma to Up-Regulate MHC Class I Antigen Processing and Presentation 
Zhou, F 
2009 
Yes 
International Reviews of Immunology
ISSN: 0883-0185 
28 
3-4 
239-260 
English 
19811323 
WOS:000269198800007 
IFN-gamma up-regulates MHC class I expression and antigen
processing and presentation on cells, since IFN-gamma can induce multiple gene expressions that
are related to MHC class I antigen processing and presentation. MHC class I antigen
presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by
phosphorylated STAT1. IFN-gamma binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal
transduction via phosphorylation of JAK and STAT1 in cells. IFN-gamma up-regulates MHC class I
antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-
gamma to enhance MHC class I antigen processing and presentation were summarized in this
literature review. 
IFN-gamma; MHC class I; antigen processing and presentation; JAK/STAT signal transduction pathway