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1576434 
Journal Article 
Review 
Mouse models for human lung cancer 
Meuwissen, R; Berns, A 
2005 
1 
Genes & Development
ISSN: 0890-9369
EISSN: 1549-5477 
19 
6 
643-664 
English 
15769940 
In recent years several new mouse models for lung cancer have been described. These include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Tumorigenesis in these conditional mouse tumor models can be initiated in adult mice through Cre-recombinase-induced activation of oncogenic mutations in a subset of the cells. They present a marked improvement over mouse models that depend on carcinogen induction of tumors. These models permit us to study the consecutive steps involved in initiation and progression and allow us to address questions like the cell of origin, and the role of cancer stem cells in the maintenance of these tumors. They now need to be validated as suitable preclinical models for intervention studies in which questions with respect to therapy response and resistance can be addressed. 
Other
• Mouse Lung Tumor Workshop 2014
     Cited
     Key Reference
     Session 2 – Comparative Pathology
          Mouse Models