US EPA

1578480 

Journal Article 

Leaching and cytotoxicity of formaldehyde and methyl methacrylate from acrylic resin denture base materials 

Tsuchiya, H; Hoshino, Y; Tajima, K; Takagi, N 

1994 

Yes 

Journal of Prosthetic Dentistry
ISSN: 0022-3913 

71 

6 

618-624 

English 

8040827 

10.1016/0022-3913(94)90448-0 

WOS:A1994NP00400014 

http://://WOS:A1994NP00400014
Exit
 

Acrylic resin dentures have the potential to elicit irritation, inflammation, and an allergic response of the oral mucosa. Studies of substances leachable from acrylic resins, their cytotoxicity to cultured cells, and means of reducing their leaching were systematically conducted. Under in vivo and in vitro conditions, formaldehyde and methyl methacrylate were significantly leached into human saliva and saliva-substitute buffer, especially from autopolymerized resins. Both leachable substances showed cytotoxic potentials in the range of their leaching concentrations. Formaldehyde was cytotoxic at lower concentrations than methyl methacrylate. Preleaching in water reduced subsequent leaching of both formaldehyde and methyl methacrylate, and the amount of reduction depended on an increase in the preleaching temperatures. Immersion of acrylic resin dentures in hot water (50 degrees C) before insertion is recommended, especially for autopolymerized resins used either for rebasing or as denture base materials, to minimize the risk of adverse reactions in patients who wear acrylic resin dentures. 

Cell Count; Cells, Cultured; Denture Bases; Formaldehyde/adverse effects/ chemistry; Methylmethacrylates/adverse effects/ chemistry; Saliva/chemistry; Saliva, Artificial/chemistry; Solubility; Stomatitis, Denture/chemically induced