US EPA

1578492 

Journal Article 

The effects of merocel and glove finger tampon applications on the nasal septum mucosa of rabbits 

Titiz, A; Zeyrek, T; Ozcan, M; Sabuncuoglu, B; Yilmaz, YF; Unal, A 

2008 

1 

Rhinology
ISSN: 0300-0729 

46 

2 

112-115 

English 

18575011 

OBJECTIVE: The use of tampons after nasal septum surgery is important for both prevention of postoperative bleeding and stabilization of the nasal flaps and the septum. One of the most important factors in achieving rapid postoperative recovery is the choice of the nasal tampon material, among many, to produce minimal damage on the nasal mucosa. In this study, the histopathological effects of the glove finger and merocel tampons, which are commonly used in clinical applications, have been investigated on the nasal mucosa of rabbits.

MATERIALS AND METHODS: In this study, merocel and glove finger tampons were used for nasal packing in one-sided nasal cavities of 16 adult New Zealand rabbits. The animals were randomized into two groups, each consisting of eight animals. The tampons were removed after 48 hours.

RESULTS: Histological examination showed that if the merocel was in a glove finger, it did not create any damage to mucosal integrity and lamina propria. However, in the group where merocel was used directly, the epithelium of the nasal mucosa was shortened and demonstrated loss of cilia and in four of the eight specimens, it was partly from lamina propria.

CONCLUSION: It is concluded that the use of merocel in glove finger tampon leads to a lesser degree of damage in the lamina propria, and may facilitate rapid mucosal wound healing postoperatively. 

Animals; Cilia/drug effects; Formaldehyde/administration & dosage/ pharmacology; Gloves, Surgical; Hemostatics/administration & dosage/ pharmacology; Nasal Mucosa/ drug effects/pathology/surgery; Nasal Septum/ drug effects/pathology/surgery; Polyvinyl Alcohol/administration & dosage/ pharmacology; Rabbits; Tampons, Surgical