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1579078 
Journal Article 
Determination of formaldehyde in urine by headspace gas chromatography 
Takeuchi, A; Takigawa, T; Abe, M; Kawai, T; Endo, Y; Yasugi, T; Endo, G; Ogino, K 
2007 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
79 
1 
1-4 
English 
17618393 
WOS:000248910900001 
Formaldehyde is a carcinogen to which humans are exposed
daily, but few methods are available to quantify formaldehyde in biological samples. We developed
a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by
derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine, using a headspace sampler
coupled to a gas chromatograph equipped with an electron capture detector. The detection limit
was 1.08 mu g/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration
of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 mu g/L.
This method can be used successfully to measure formaldehyde in urine. 
formaldehyde; headspace analysis; gas chromatography; human urine; O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine 
• Formaldehyde [archived]
     LHP MOA
          Screened
               Irrelevant species / model
          Cited
• IRIS Formaldehyde (Inhalation) [Final 2024]
     Literature Indexing
          Other sources and cited references
     Literature Identification
          Mechanistic Studies of Lymphohematopoietic Cancer, Genotoxicity
               Excluded
PFAS
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine