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1610120 
Journal Article 
Electrospinning of type I collagen and PCL nanofibers using acetic acid 
Chakrapani, VY; Gnanamani, A; Giridev, VR; Madhusoothanan, M; Sekaran, G 
2012 
Yes 
Journal of Applied Polymer Science
ISSN: 0021-8995
EISSN: 1097-4628 
125 
4 
3221-3227 
WOS:000303596200088 
Fabrication of nanofibrous biomaterials based on natural
materials (collagen, gelatin, etc.) through various techniques is an important research topic.
Electrospinning, a well-established technique for nanofiber production has also been extended for
producing nanofibrous structures of natural materials. Collagen nanofiber production utilizes
hexafluoro isopropanol (HFIP) as a solvent for electrospinning. Research efforts are now focused
on replacing HFIP with an environmentally benign solvent. In this study, electrospinning of Type
I collagen of bovine skin with polycaprolactone (PCL) as a blend and an environmentally benign
solvent, acetic acid, was carried out. The samples produced were subjected to contact angle
measurements, porosity estimation, SEM, FTIR, TGA, and DSC. Nanofibers in the range of 100-200 nm
were produced with an optimum porosity of 60%. The instrumental analyses confirm the physical
interaction between collagen and PCL. Electrospinning of collagen in an environmentally benign
solvent has been carried out and its usage in tissue engineering is being investigated by our
research group. (C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 
electrospinning; biomaterial; biopolymer; nanofibers