US EPA

1611620 

Journal Article 

Synthesis and Antimicrobial Property of 2-(2-nitrovinyl) Furan 

Alabi, KA; Owolabi, BJ 

2012 

Yes 

Journal of Pure and Applied Microbiology
ISSN: 0973-7510 

6 

1 

131-134 

WOS:000304500700019 

This work aimed at synthesis and antimicrobial evaluation of
the potency of 2-(2-Nitrovinyl) Furan. The condensation of furfural with nitromethane was
conducted in sodium tertiary butoxide. The product's characterization carried out with H-1 and
C-13 NMR spectrometry and thermal analysis. The 2-(2-Nitrovinyl) Furan was tested with
conventional antibiotics (Ridomil plus, Benomyl, Streptomcin, Tetracycline and Amphicillin)
against pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and
Salmonella typhimurium) and molds (Fusarium solani and Cercosspora cucurbitarum) and yeast
(Candida albicans) by agar well diffusion method. Characterization showed that the reaction
product is 2-(2-Nitrovinyl) Furan and the product is crystalline yellow. According to the thermal
analysis, the product's melting point was between 68 degrees C and 70 degrees C. The synthesized
2-(2-Nitrovinyl) Furan prevented the growth of the S. typhimurium, C. cucurbitarum, E solani and
C. albicans at 100%, P aeruginosa and Staph. aureus at 96%, E. coli at 80% inhibition. In
contrast, commercial antibiotics produced zones of growth inhibition in the range of 14% to 100%.
Therefore, the synthesized 2-(2-Nitrovinyl) Furan appeared to be more powerful antimicrobial than
the conventional antibiotics (Ridomil plus, Benomyl, Streptomcin, Tetracycline and Amphicillin). 

2-(2-Nitrovinyl) Furan; Synthesis; Chemical Structure; Antimicrobial efficacy