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1611879 
Journal Article 
A Novel Method for the Synthesis of Actarit 
Zhou, LiYi; Yang, Jun; Yan, XiQ; Pan, YanJ; Wu, F; Zhang, J; Yan, FuLin; Lu, GZ 
2012 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
24 
4 
1538-1540 
WOS:000300464200030 
The specific synthetic route to synthesize the actarit (4 acetyl-amino phenylacetic acid) by acylation was designed in which p-amino benzaldehyde (a) and
nitromethane (b) was used as the raw materials, through Knoevenagel reaction. The selective
reduction of potassium borohydride and p-amino phenyl acetic acid to be oxidated under the acidic
conditions. After optimization of the synthetic conditions, the I yield of each step was more
than 85 %. The synthesized compound was confirmed by the elemental analysis and nuclear magnetic
resonance. Because of the readily available raw materials, simple operations, high yield and
avoiding highly toxic reagents in the synthesis of actarit (4-acetyl-amino phenylacetic acid),
the synthetic route is suitable for the industrial production. 
Actarit; Knoevenagel reaction; Selective reduction; Reaction mechanism