The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1617772

Reference Type

Journal Article

Subtype

Review

Title

The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review

Author(s)

Ragheb, A; Attia, A; Eldin, WS; Elbarbry, F; Gazarin, S; Shoker, A

Year

2009

Is Peer Reviewed?

Journal

Saudi Journal of Kidney Diseases and Transplantation
ISSN: 1319-2442

Volume

Issue

Page Numbers

741-752

Language

English

PMID

19736468

Abstract

Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti-oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.