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1619553 
Journal Article 
Some biochemical effects of isopropyl myristate and squalane on rabbit skin 
Komatsu, H; Asaba, K; Suzuki, M 
1979 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
30 
5 
263-278 
English 
WOS:A1979HR60900002 
A biochemical method was employed to study the response of rabbit skin to isopropyl myristate, squalane, and decane. The results showed that decane damaged the skin so severely that the biosyntheses of lipids, RNA and DNA were reduced markedly for the first 3 days after application, but increased rapidly after that due to the repair. The effect of squalane was found to be weaker than that of isopropyl myristate, though both oils induced the stimulation of biosynthese in the epidermis. The magnitude of the biochemical effects of the 3 oils on the skin was increased in the order of squalane, isopropyl myristate and decane, which was consistent with the results of macroscopic and histological observations. From the profiles of the effects, it is postulated that the repairing processes are controlled by some feedback mechanisms. 
Isopropyl myristate; effects; skin; Squalane; Decane; Toxicity; effects; Methodology; oils; Oils; cosmetics; toxicity 
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